Valorisation of black mulberry and grape seeds: Chemical characterization and bioactive potential

Grape (Vitis vinifera L. var. Albariño) and mulberry (Morus nigra L.) seeds pomace were characterized in terms of tocopherols, organic acids, phenolic compounds bioactive properties. Higher contents tocopherols (28 ± 1 mg/100 g fw) obtained mulberry, whilst grape richer acids (79 4 fw). The analysis hydroethanolic extracts characterised by catechin oligomers (36.0 0.3 mg/g) ellagic acid derivatives (3.14 0.02 mg/g). Both exhibited high antimicrobial activity against multiresistant Staphylococcus aureus MIC = 5 mg/mL) no cytotoxicity carcinogenic non-tumour primary liver (PLP) cells. Mulberry revealed the strongest inhibition (p < 0.05) thiobarbituric reactive substances (IC50 23 2 µg/mL) oxidative haemolysis at 60 min 46.0 0.8 µg/mL). seed by-products could be exploited for developing antioxidant-rich ingredients with health benefits industrial application.